PLEIOTROPY CONSTRAINS THE EVOLUTION OF PROTEIN BUT NOT REGULATORY SEQUENCES IN A TRANSCRIPTION REGULATORY NETWORK INFLUENCING COMPLEX SOCIAL BEHAVIOURS

It is increasingly apparent that genes and networks that influence complex behaviour are evolutionary conserved, which is paradoxical considering that behaviour is labile over evolutionary timescales.How does adaptive change in behaviour arise if behaviour is controlled by conserved, pleiotropic, and likely evolutionary constrained natio celebrate

The new CERN Single-Sign-On (SSO), built around an open source stack, has been in production for over a year and many CERN users are already familiar with its approach to authentication, either as a developer or as an end user.What is visible upon logging in, however, is only the tip of the iceberg.Behind the scenes there has been a significant amo

Abstract Background Headache is the dominant factor for quality of life related disability in idiopathic intracranial hypertension (IIH) and typically has migraine-like characteristics.There are currently no evidence-based therapeutics for headache in IIH, and consequently this is an important unmet clinical need.Case series We report a series of s

Introduction.Hepatic peribiliary cysts (HPCs) usually originate due to the cystic dilatation dea eyewear of the intrahepatic extramural peribiliary glands.We describe our rare experience of pure laparoscopic left hemihepatectomy (PLLH) in a patient with HPCs accompanied by a component of biliary intraepithelial neoplasia (BilIN).Case Presentation.A